BIOL 300 Lecture Notes - Lecture 14: Protein Domain, Fibroblast Growth Factor Receptor 2, Wild Type
5 Mar 2018
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When u2 binds, it will look for upstream u1. However, since this u1 was enable to bind, u2 will interact with the next. U1 available in the next exon (the blue exon further upstream) this results in the skipping of the red exon. However, the branch point could still be recognized by u2: here, u11 is basically equivalent to u1. Upstream u1 will interact with u2, and upstream u11 will interact with u12 it will result in the skipping of the green exon: 2. These exons may be regulated by the combination of splicing activators or repressors. 38,016 different isoforms can form (12 x 48 x 33 x 2 = 38,016: the drosophila genome only contains approximately 15,000 protein coding genes! In the wild type, you can see that the dendrites and the axons have to spread out, however you never see the dendrites crossing over (one of the mechanism to ensure that they spread out)
