BIOL 303 Lecture Notes - Lecture 15: Yolk, Intermediate Mesoderm, Polarity In Embryogenesis
27 Apr 2016
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Review lecture14 : s21 (final) recall neuwnkoop center: has both b-cat and veg1 (tgf-b) able to induce dorsal mesoderm = b-cat and veg1 induce exp of dorsal mesoderm specific genes (noggin, chordin, foll). Thruout blastula, but not in dorsal mesoderm, we have bmp4. Bmp can induce vental meso as well as inducing ectoderm to become epidermis. If take animal cap and leave it alone or put bmp, the ectoderm epidermis, but if add nog,chordin. fol (dorsal meso specific genes) , ecotoderm will become neural tissue. Nog,chord,fol are bmp inhibitors,1)inducing dorsal meso ,2) ectoderm neural tissue. So there"s a gradient of bmp in mesoderm that specifies type of mesoderm: No bmp: dorsal meso / high bmp: vetnral meso ex blood / intermediate bmp: intermediate mesoderm ex heart. S39 anterior-posterior axis of neural tissue: during gastrulation, dorsal meso involutes thru dbl and migrates towards future anterior end and lies right underneath ectoderm.
