ANAT 262 Lecture Notes - Lecture 18: Clathrin, Endosome, Pinocytosis

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 262
• Professor: Ursula Stochaj

Document Summary

Endocytosis of particles: phagocytosis, brings in for destruction. Endocytosis hijacked by some pathogens, use env"t to multiply. Er golgi very simple, only one way. Golgi pm diff vesicles, little more complicated. Pinocytosis (old term): cell drinking, contains fluids & membrane. Most endocytosis is pinocytosis (unless say otherwise in lecture) Phagocytosis only occurs in specialized cell types e. g. macrophages, neutrophils (garbage disposal or defense mechanism) Autophagy (eating self) not really endocytic pathway; puts membrane around & fuses w/lysosomes phagocell. Endocytic vesicle: clathrin & non-clathrin, each of endocytosis. Clathrin: coat protein; ap-2 (adaptor) on cell surface bind to receptors on cell surface concentrate receptors on surface into vesicle bind ligands into vesicle efficiently lose clathrin coat. Ldl binding to surface on inside of cell, concentrating in pit. Lipoproteins go all the way to lysosomes in endocytic pathway, receptors recycled back to surface. Early endosome: made from fusion of endocytic vesicles, mildly acidic (~5. 5), proton pump pumping in h+