ANAT 322 Lecture 26: April 9
3 Sep 2016
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Document Summary
Synaptic inputs to pvn cells: npy, agrp, a-msh. Thyroid linked to energy homeostatis central control. Msh increases trh expression in pvn neurons expressing the mcr-4. Fast + add leptin strong signal comparable to when fed. Leptin in energy homeostasis: normal fed, fasting animals, note the marked reduction in hybridization signal by fasting, protrh mrna levels are restored to normal in fasting animals administered leptin, See slide 100 for effects of leptin on serum t4 levels. Trh is the major driver ( positive regulator) of t4 synthesis. T3 is a negative regulator of trh gene expression. T3 increases expression of the trh peptidase at the nerve ending. Thus post-translational control of trh expression is germaine. Fast + leptin: rise t4, but not to baseline when fed. Leptin, an adipocyte-derived hormone, conveys information about energy stores of the periphery to the hypothalamic nuclei.
