ANAT 322 Lecture Notes - Lecture 1: Cell Membrane, Baroreceptor, Vasoconstriction
3 Sep 2016
School
Department
Course
Professor
Document Summary
Oxytocin & vasopressin stored in large dense core vesicles transported through axon to axon terminal released. Axon through internal layer of medial eminence to posterior pituitary (mainly) general circulation. Arrows pointing to perinuclear area: not many cells, fibres from limbic systems. Ventral: almost lack of neurons; mainly glial; ventral glial lamina. Vasopressin localized in soma; send axons to ventral part of nucleus. 9 peptides, differ in positions 3 & 8. Neurophysins for packaging of avp & ot in vesicles. Herring bodies: vesicles at axon terminals containing avp & ot. 3 exons each, promoters inversed in location (ot, avp promoter, ot promoter, avp) Precursor contains hormone response element; conserved b/w species. Exon 1: signal, ot, and gkr (consensus sequence, where prohormone convertase cleaves) separate ot & neurophysin (other 2 exons) Son mainly magnocellular neurons containing ot & avp. Avp in more neurons, more ventral & posterior. Avp mainly in magnocellular, but some can also be synthesized in parvocellular.
