ANAT 322 Lecture Notes - Lecture 1: Pituitary Adenoma, Master Clock, Acromegaly

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 322
• Professor: David Ragsdale

Document Summary

Vasopressin & oxytocin at posterior pituitary into general circulation. Nerves end in posterior pituitary, contact capillaries into blood. Other peptides made in periphery, signal to brain. Most neuropeptide neurons in medial basal hypothalamus project to median eminence (hypophyseal portal circulation) anterior pituitary diff cells producing diff hormones (acth, Oxytocin & vasopressin neurons project to posterior pituitary uterus contractions & renal balance. Need to release into median eminence portal vein anterior pituitary. Not peptides: epinephrine, norepinephrine , dopamine, serotonin, gaba. Somatostatin can be neurohormone & neurotransmitter; has paracrine action; crf also has diff effects. Most neuropeptides have signal peptide in initial structure. Pc1 & 2 cleave diff sites at large pomc precursor into shorter acth, b-endorphin, a-msh, y- Pomc processed differently b/w anterior & intermediate pituitary. Anterior pituitary: pomc acth & b-lph (no opiate activity, not further processed) Arcuate & intermediate pituitary & nts: b-lph gets further processed b-endorphins 1-27 & 1-