ANAT 365 Lecture Notes - Lecture 22: Calcitonin Receptor, Heterotrimeric G Protein, Endosome
19 Jul 2016
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Document Summary
N-terminal extracellular (ligand binding), c-terminus intracellular (regulatory interactions w/associated proteins & kinases) Still don"t know ligand of many specific receptors though. All stimuli from outside, receptor needs to be at pm for effect & signal. Trans: loose network of cisterns, shipping compartment & targeting decisions. Can be sorted from tgn, also back to tgn & other places. Clr bound to ramp1 goes to cell surface, now functional receptor (bind neuropeptide) Ramp1 not bound clr stays at golgi w/ramp2 or 3: binds diff peptide hormone at cell surface, am receptor. Ramp as chaperone to bring clr from golgi to surface, and gives receptor its activity (ligand specificity) Related calcitonin receptor (ctr) at cell surface by itself. With ramp binds amylin, depending on which ramp ramp for diff ligand specificity and differential receptor regulation (receptor either degraded after ligand binding, or recycled back) 4 functions of ramp bolded and underlined. Vpac1r binding ramp2 changes receptor signalling (activity modifying)
