ANAT 416 Lecture Notes - Lecture 13: Excitatory Synapse, Gephyrin, Syntaxin
3 Jun 2020
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Feb 21 // lec 13 // neural connectivity 1 // h takahashi. Lots of mitochondria = energy for vesicular processes, calcium buffer for calcium buildup. Vglut or vgat to transport glu/gaba into vesicle. Rim, rab = bind ca++ channel = dock vesicle. Synaptobrevin + snap25 = interact with pm syntaxin to form snare complex = prime for release. Synaptotagmin = ca++ sensor = triggers fusion of vesicle to pm to form pore to release vesicle contents. Synapse: highly-organized neuronal junction; a functional unit for information processing. Synaptic cleft is about 20-30nm, while diameter of synaptic vesicle is about 40nm. Translocation to active zone to release nts in response to increased ca influx. Ca channels are voltage dependent and open upon ap. Both exci/inhi release nts, so presyn = similar. Axon contacts dendrite/soma via filopodia = neuron-neuron interaction is the trigger. Proper targeting of glu and gaba receptors on postsynaptic membrane. Asymmetric, trans-cellular, chemically-matched required for both types of synapse.
