ANSC 234 Lecture Notes - Lecture 3: Mitogen-Activated Protein Kinase, Nuclear Localization Sequence, Gsk-3
30 Oct 2017
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Document Summary
Irs1 gets phosphorylated and it target is p1-3k. Pip3 has a phosphate added to the 3 spot and it stays in the membrane. It can be reversed by pten so the pip3 goes back to pip2. Pkb binds to the phosphorylated part of the pip3, it cannot bind to pip2 (only 3 because of the structure) Gsk3 is active when it is not phosphorylated, but pkb inactivates it by phosphorylating it. Gs is active when it is not phosphorylated and it synthesizes glycogen. Erythropoietin binds to its receptor and then the receptor is phosphorylated. When jak binds to the receptor is activated. Jak provides a physical structure in which stat can bind. Stat can only bind to receptor when jak is bounded to the receptor but jak can only bind when. When that happens it gets out and forms a dimer. When you have the dimer it then can go to the nucleus.
