BIOL 202 Lecture Notes - Research In Computational Molecular Biology, Centromere, Product Rule

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A locus is a small part of the genome which is responsible for a certain phenotype, or contributes to a phenotype. Huntington"s disease is a mutation in which the individuals suffering have too many copies of a trinucleotide repeats 5"-cag-3": this was determines through genetic mapping of the disease"s locus on chromosome 4. Therefore, the frequency of recombination is usually much less than 50% For example, take the following 2 loci on the fruit fly genome: pr+ or pr code for red or purple eyes respectively, vg+ or vg codes normal of vestigial (short) wings respectively. One important rule in genetic mapping is that longer regions between the genes of interest have a higher frequency of recombination. In fact, the distance between loci are measures in map units, which have been designed so that the number of map units between two loci is equal to the frequency of recombination.

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