BIOL 303 Lecture Notes - Lecture 10: Drosophila Melanogaster, Gap Gene, Homeobox
19 Feb 2018
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Nuclei move to the periphery and cellularization, beginning of zygotic transcription. Self cross offspring to find homozygous of mutant allele. Sometimes hard to get a mendelian mutation because of other mutations in the background & epistasis. Screening for maternal effect lethal genes (mel) phenotype of offspring dependent on genotype of mother. Lof-lost of ap segment polarity e. g. dentical bands show on each segment. Nurse cells: sibling cells to oocytes; transports mrna and proteins into oocyte (both copies) Certain parts can be affected independently (a is specified independently from. Lof: lost anterior structure and develops into posterior structures instead (necessary) Move bcd mrna localization induces head morphogenesis anywhere else on the body (sufficient)-a morphogen. Selectively localized before fertilization via 3" utr to anterior cortex. Translated after fertilization by changing poly a tail length. Transcription activation of orthodenticle and hunchback and knirps (concentration dependent)
