BIOC 212 Lecture Notes - Lecture 7: Günter Blobel, Secretory Protein, Translocon
22 Mar 2017
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Bioc 212 lecture 7 jason young membranes 3. Targeting signals: the sequence of a protein can encode a signal or signals that specify its organelle localization, targeting signals: Are often independent from the structure or biochemical function of proteins. May be removed by proteolysis after targeting is complete, or form part of the recognized by their pattern, but usually not an exact sequence native structure: targeting steps: recognize a signal on a protein. Connect protein to the membrane translocate protein into or across the membrane. Secretory signal sequences: secretory signal sequences have a typical pattern of amino acids, hydrophobic central region 8 or more residues long, with short polar regions on each side. In many cases, signal sequences are at the n-terminus: shorter hydrophobic regions (8-16 residues, often cleaved off after translocation. In other cases, signal sequences can be in different places in the protein and become. Tm helices (not cleaved off) longer hydrophobic region (18-24 residues) termed signal anchors.
