BIOC 212 Lecture Notes - Lecture 11: Cell Culture, Dna Mismatch Repair, Kidney Cancer
17 Aug 2018
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Document Summary
Mouse models to mimic human cancer: knockout and transgenic mice. Activation/inactivation of one of the genes is not enough to cause a tumor, need cooperation. Take home message: any different pathways that are driving cell proliferation: most of them are driven by outside signals (receptors, negative antigrowth factors, survival signals, apoptosis signals. Signal is transmitted through the cell through kinases and other signaling molecules in a cascade to get to the nucleus. Nucleus: change in gene expression resulting in proliferation or survival, etc. Arrow = stimulatory interaction, meaning that it is a proto-oncogene activates something. Bar = inhibitory interaction, tumor suppressor gene, stops something. Drugs: aspirin (penetrate the cell wall and get in), ab (inhibits complex by binding extracellular regions as it won"t go in the cell: sequence tumour to find mutations in most of the pathways. Red = tumor suppressor (lost in cancer or inactivated)
