BIOC 212 Lecture Notes - N-Terminus, Disulfide, Secretion

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Intro to proteins what they are what they do, intro to co-chaperones (proteins responsible in folding of other proteins, how they work in folding and degradation (removal of misfolded proteins) How proteins can be chemically modified and how they can turn into amyloids. Next section, membranes, how they are formed, from lipids. Basic building blocks of cells, bodies, made from aa, made by ribosomes. Default: in the cell( means human/mammalian cells) cells are bound by membranes, have intracellular structures labelled in the diagram. Cytosol is full of organelles, intracellular proteins, macromolecules, all essential to performing processes of life. Some review: proteins are the main functional components in cells. Dna is translated to rna, rna transcribed into proteins. Genes are linear, therefore proteins are made as linear polypeptide sequences, but they must fold into 3d structures. By folding, it becomes more physically stable internally and it exposes functional surfaces it needs to interact with other molecules.

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