BIOC 311 Lecture Notes - Lecture 27: Post-Translational Modification, Energy Homeostasis, Kidney Failure
12 Feb 2020
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Document Summary
Energy homeostasis: balanced regulation of fuel intake, storage and expenditure. Disturbance of energy homeostasis can contribute to. Short term regulation: obesity, diabetes, heart failure, kidney failure, nafld, cancer, seconds to minutes, through allosteric control, post-translational modifications (ptms) E. g. phosphorylation: usually under hormonal control. Most metabolic regulations benefit from a coordination of: hours to days to years, requires transcriptional regulation of metabolic genes, allosteric regulation, post-translational modification, transcriptional regulation. Transcriptional control requires specific signals to be transduced to the cell nucleus. To understand transcriptional control of specific metabolic responses, we need to know: here, individual genes or gene networks are targeted for regulation, events upstream of transcriptional activity, The route of the signal to the nucleus, via (for example: e. g. glucagon, glucocorticoids, nutrient, signalling pathways, protein cleavage, direct activation, the molecular mechanisms that regulate gene expression. These depend on the genes being targeted. This step can generate further signals, for example: Change of expression of metabolic enzymes (through transcription of.
