BIOC 311 Lecture Notes - Lecture 30: Leptin Receptor, Adenylyl Cyclase, Gastric Acid
12 Feb 2020
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If we get to 75% response to the mercury course evaluations, you get a 2% bonus on the final exam. Dephosphorylation by ptp-1b and pten: ptb-1b dephosphorylates the receptor, pten dephosphorylates pip3 back to pip2. Serpentine receptors: gpcrs (e. g. adrenergic receptors, ghrelin receptors, have 7 transmembrane domains, activate either: G q subunit plc etc: switched off by : arrestin) Phosphorylation of receptors (recruits ark (which is activated by pka) and - They are either degraded in the lysosome. Or recycled back to the surface (with the -arrestin and the ligand dissociated: this is resensitization. Characteristics: 16 kda protein produced by adipose tissue and the stomach upon food intake, leptin acts as a signal of satiety. Overview: secreted towards the gastric lumen into the gastric juice, passes into the circulation in duodenum, then goes through the bbb to the brain, binds leptin receptor (ob-r) in hypothalamus. Leptin-deficient humans (rare) are obese and can be treated with leptin.
