BIOC 311 Lecture Notes - Lecture 24: Inosinic Acid, Ribose 5-Phosphate, Inosine

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Maxime Denis

Document Summary

Know the names and recognize the structures of the different molecules and their differences, as it will help for understanding future lectures and the exam. Base: aromatic backbone, either purine bicyclic compound or pyrimidine ring. Numbering is always done in order to make the most electronegative atoms (e. g. nitrogen in the amino bases) have the lowest numbers possible: purines, pyrimidines. Nitrogens are atom 1, 3, 7 and 9. Nitrogen 9 (on the five-member ring) connects to ribose. Nitrogen 1 connects to ribose (which is why, on pyrimidines, it"s atom 1) Sugars are numbered with primes: note: the numbers for bases are unprimed, 2 types: Aka ribose missing a hydroxyl group at carbon 2". Both sugars, upon binding to a base via -glycosidic bond, become locked in their ring (furanose) conformation. Adenosine (ado, a) (mono)nucleotide (x = ribose phosphate) Not to be confused with thiamine (a vitamin b) Watch out, the naming scheme for purines and pyrimidines are different.