BIOC 311 Lecture 21: Fatty Acid Elongation and Desaturation

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Lecture 21: fatty acid elongation and desaturation, tag synthesis, and fatty acid storage and. This is done by thiokinase or acyl-coa synthetase. This requires an atp to give adp and ppi. Can derivatize it --> elongate it or desaturate it. We need longer chain fatty acids for specific functions. Done facing the cytoplasm - no transport issue. Add a coa to the fatty acid to form fatty-acyl coa. Can be done with c10 and up. *recognize names of enzymes and know their function. Source of two carbons is the acetyl coa. Makes a keto-acyl and the same processes occur like microsomal elongation. Differences between mitochondrial and microsomal elongation: 1st reduction is using nadh, no co2 because using acetyl-coa as the two carbons, different enzymes, coa substrates and intermediates, not acp"s. Similarities: same chemistry, same result, use power from cofactor, still use nadph for half the process. Genetic desaturation of fa in the er (microsomal)

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