BIOC 311 Lecture Notes - Lecture 33: Diabetes Mellitus Type 2, Coronary Artery Disease, Diabetes Mellitus Type 1
15 Dec 2015
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Document Summary
A defect in either hormone secretion or in the function of their receptors could cause chronic diseases; e. g. insulin resistance syndrome. The insulin resistance syndrome, also referred to as the "metabolic syndrome" or "syndrome x", is associated with a primary cellular defect in insulin action (insulin resistance) and a compensatory increase in insulin secretion. The combination of insulin resistance and subsequent hyperinsulinaemia causes a number of metabolic and cardiovascular changes that result in a syndrome typically characterized by type 2 diabetes, obesity, dyslipidaemia, coronary artery disease and hypertension. Diabetes: insulin is either absent or secreted at very low levels or cannot stimulate its target cells despite its availability. Nov. 25, 2015: although these patients have a very high level of insulin in their blood, the cells are insulin- resistant. Mody (maturity onset diabetes of the young: mody gene mutations exist which cause diabetes. Is secreted in response to high glucose in the blood.
