BIOC 311 Lecture 21: Lecture_21
18 Jun 2016
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Once you have palmitate, thiokinase with atp will form coa version of palmitate. > derivatize it by (1) elongation or (2) desaturation. Major pathway of elongation process in humans: happening in smooth er (facing cytoplasm) Same purposes than fas (fas: formation of c-c bond and fully saturated alkane) Acyl-coa (c10 and up, and unsaturated/saturated) and malonyl-coa are the substrates. Differences with fas: worked upon as coa molecules and individual enzymes participate rather than one big complex enzyme. Bond formed between malonyl-coa and carbonyl c of acyl-coa, forming ketoacyl-coa intermediate (condensation) by 3-ketoacyl-coa synthase. Reduction reaction using nadph forming hydroxyacyl-coa by 3-ketoacyl-coa reductase. Dehydration reaction: introduces double bond making intermediate an enoyl- Reduction reaction using nadph forming fully saturated chain (2c added on) by. Alkane chain + 2c can go off to get (1) desaturated, (2) used or (3) repeat the cycle of elongation.
