BIOC 311 Lecture Notes - Lecture 25: Ketone, Benzene, Vitamin K
18 Jun 2016
School
Department
Course
Professor
Document Summary
Plamitoyl-coa and serine forms an intermediate that will be reduced by nadph and. An acyl group will then be added on sphingane by acyl-coa transferase forming a certain intermediate. This intermediate will be converted to ceramide through oxidative power of fad (addition of double bond, looks like dag) 2 acetyl-coa -> 4c -> through hmg-coa synthase generating hmg-coa -> utilizes. Enzymes that use nadph: hmg-coa reductase, squaline synthase and squaline monoxigenase. 4 enzymes that we need to know hmg-coa synthase, hmg-coa reductase, squaline synthase and squaline monoxigenase. Activated isoprene (5c) is the precursor of several compounds hence meaning tha theses compounds are by-products of cholesterol synthesis:: If cholesterol synthesis is blocked (statin for instance), we block formation of all other intermediates. Steroid hormones: progesterone, cortisol, aldosterone, testosterone, estradiol are all derived from cholesterol. Difference between testosterone and estrogen: ketone on testosterone while estrogen has a benzene ring => huge biological effects (very specific receptors)
