COMP 251 Lecture Notes - Lecture 12: Polyurea, Diabetes Mellitus Type 1, Diabetes Insipidus
24 Aug 2018
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Document Summary
Insulin and glucagon: small protein hormones and both control the glucose concentration in the blood. Insulin deficiency or absence compromises significantly the well-being of the individual. In the liver and muscle cells, it is converted to glycogen. In the adipose tissue is converted to fat and stored for later use. In many cells of the body, it is oxidized to produce energy. Insulin receptor: membrane receptor, stimulates the insertion of glucose transport proteins stored in cytoplasm into plasma membrane. Increased lipolysis: however, the fat is inefficiently used because there is an incomplete oxidation of. Ffa and increased circulating acetoacetic acid and b-hydroxybutyric acid (metabolic acidosis) and acetone (ketosis - acetone smell in breath of untreated diabetics: leads to, decreased blood ph, diabetic coma (unless treatment is provided) In diabetic comas, acidosis and associated electrolyte imbalance must be corrected in addition to insulin administration.
