EAST 501 Lecture Notes - Lecture 13: Surfactant, Vasovasostomy, Male Contraceptive
21 Jun 2018
School
Department
Course
Professor
Feb 5th – Lec 13 Robaire
Presentation: Male infertility
PHARMACOLOGICAL AGENTS
-contraception in general is the most difficult type of drug design in pharmacology
-for a contraceptive if it works at 80% it is useful
-you want to side effects, 100% effective, totally reversible, inexpensive, easily administered
-for female contraceptive – 1 egg/mont
-mall contraceptive – 1M sperm/heart beat
METHODS OF CONTRCEPTION
-condoms
obarrier methods
o>95% if you use absolutely right
oneed to use at a barrier method
-vasectomy
o100% effective
omostly irreversibly vasovasostomy (this is the reversal surgery)
in 50% were you do the reversal surgery and the sperm come back the male is no longer
the sperm produce foreign sperm the body develops Abs to the sperm
in terms of surgery we are really good at withdrawing it
-withdrawal
othe first fraction of semen is the richest in sperm most motile and active sperm
-spermicides
oNonoxynol-9
a nonionic surfactant
developed as a detergent
works by denaturing membranes
same ingredients found in most spermicidal creams, jellies, foams, gel, film, and suppositories
failure rate 10-28% you only need 1 sperm to work
does not protect from STD
these types of drugs would no longer be accepted by Health Canada in approved
-hormonal (injections/implants/creams)
otestosterone alone
otestosterone + LHRH analog
otestosterone + estrogen
otestosterone + progesterone e
-non hormonal approaches
-imjunocontraception
TESTOSTERONE ALONE
these were the initial studies
T acts on the sertoli cells to produce spermatogenesis
FSH is essential at the initiation of spermatogenesis, but it is not necessary for maintenance
if you block FSH you have 0 effect on spermatogenesis
if you did not have FSH during puberty, you will not have normal level of spermatogenesis
if you get rid of LH or T, you will get rid of spermatogenesis
Steroid-containing Plydimethylsilozane (PDS) capsule
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Methods of contrception condoms: barrier methods, >95% if you use absolutely right, need to use at a barrier method vasectomy, 100% effective, mostly irreversibly vasovasostomy (this is the reversal surgery) T acts on the sertoli cells to produce spermatogenesis. Steroid-containing plydimethylsilozane (pds) capsule liphophilid substanses will melt through the membrane and into whatever fluid is on the other side they were putting implants of different lengths in rabbits looking at the serum t level. Gnrh needs to be supplemented with t, or else there is a sort of chemical castration estradiol is essential for male fertility. Percent of subjects with sperm cocnetnration suppressed with testosterone (t) and nestrone (nes - Prostestin) looking at men who are azoospermic or. Robaire the effect you have is pretty minimal. Treatmnet: 200mg net-en (200mg/ml) + 1000mg tu (250mg/ml) b y 2 seperate gluteal injections every 8 weeks for yup to 4 injection visits the lh goes down, stays lh stop treatmet comes back.
