EDKP 395 Lecture Notes - Lecture 2: Titin, Neurotransmitter, Myoglobin
27 Mar 2018
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Document Summary
Sarcoplasmic reticulum: lattice like network of tubular channels and vesicles that provides structural integrity to the cell. Reticulum triads: transverse tubules (t-tubules) flanked by terminal cisternae allow wave of depol (act. p) to spread rapidly from muscle fibers outer to inner environment to make muscle contraction. Contains biologic pumps that up calcium from fibers sarcoplasm thus producing a ca2 gradient between sr (higher sr) and sarcoplasm (lower ca) Ex: atp, ca, mg, na, k, cl, amino acids, fats, glycogen. Arteries and veins lie parallel to individual muscle fibers and provide a rich vascular supply. Capillary microcirculation ensures adequate delivery of o2, nutrients and hormones from arterial circulation, and removal of heat and metabolic biproducts (ex: co2) in venous circulation. Many areas where nutrients can diffuse into the cell and where aste products can diffuse out. Within each muscle fibers composed of myofibrils that are arrangement in parallel along the fibres length.
