EDKP 485 Lecture Notes - Lecture 19: Afterload, Aldosterone, Renin
23 Mar 2017
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Document Summary
Conspiracy of maladaptation - pathophysiology of chf . Chf = begins after index event that produces initial decline in cardiac pumping capacity. Event led to chf with co & sv. Compensatory mechanisms beneficial = help to restore cardiovascular function & Compensatory mechanisms detrimental = lead to secondary damage of. Myocardium & ventricular remodeling worsening of chf & symptomatic. 1- index event = poor ventricular function / myocardial damage chf heart failure. 2- chronic impaired co & sv = map so get blood pressure error. *activate reflex response to raise blood pressure map so. Sympathetic tone = tvk / tvr so map sodium & fluid retention - water & electrolytes. Result long-term = further stress on ventricular wall & dilation ventricular remodeling. *leading to further worsening of ventricular function & chf heart failure. Compensatory mechanisms = factors that change blood pressure: frank-starling. Remodeling: frank-starling mechanism - pathophysiology of chf. Myocardial contractility decrease so reduced ejection fraction.
