ENVB 437 Lecture Notes - Lecture 16: Biobank, Personalized Medicine, Macular Degeneration
4 Jun 2018
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Eukaryotic cells and viruses – lecture 16 (March 14th,2018)
Slide 61
- Homozygotes clustered on the axis and heterozygotes both alleles running in the mid dle
slide 62
- All the data that is being collected in the photo-optic tubes is being animated
Slide 64
- You can generate a gene expression profile by modifying how you use the beads
o The illumine based machines are common in sequencing companies
Slide 65
- Age-related macular degeneration
o They were able to identify an SNP that was associated with AMV
o Designing new treatments according to which genes were identified
▪ Suggested that it was inflammatory, which allowed it to be treated appropriately
Slide 66
- Associated loci with various diseases (SNP maps) to be used to get all kinds of info
Slide 67
- Conditions that have low penetrance
o Psychological disorders for example have low penetrance
▪ Not looking for a single allele affect, it might be a combination of different things in different
alleles
- The ones that have high penetrance have an observable phenotype
- The calcium channels were communal to all the disorders, so it might be possible to find a new therapeutic
target
Slide 68
- They highlight earwax
o Dry as opposed to oily, yellow ear wax
▪ Gene locus associated with ear wax
Slide 69
- SNPs can be used in forensic investigations
o From DNA on a crime scene, all this can be identified
- Found by genomic sequence
Slide 70
- They intervened with Neanderthals and brought the genes into the modern genomes
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Document Summary
Eukaryotic cells and viruses lecture 16 (march 14th,2018) Homozygotes clustered on the axis and heterozygotes both alleles running in the mid dle slide 62. All the data that is being collected in the photo-optic tubes is being animated. You can generate a gene expression profile by modifying how you use the beads: the illumine based machines are common in sequencing companies. Age-related macular degeneration: they were able to identify an snp that was associated with amv, designing new treatments according to which genes were identified, suggested that it was inflammatory, which allowed it to be treated appropriately. Associated loci with various diseases (snp maps) to be used to get all kinds of info. Conditions that have low penetrance: psychological disorders for example have low penetrance, not looking for a single allele affect, it might be a combination of different things in different alleles. The ones that have high penetrance have an observable phenotype.
