INDS 211 Lecture Notes - Lecture 9: Umbilical Cord, Decidua, Amnion

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 211
• Professor: Helene Weibel

Document Summary

Development of villi, maternal blood goes into a pool. Major placental disease: infection, villitis: hematogenous infection transmitted from the mother; less common due to screening, histology: presence of lymphocytic inflammatory infiltrates in trophoblastic villi, viral inclusions, microbiology: torch (toxoplasmosis, rubella, In a non-pregnant state, uterine vessels are coiled and of equal width along their length. In a normal pregnancy, under the influence of hormones, vessels will dilate in order to accommodate blood entering the placenta. In preeclampsia, various factors induce narrowing/constriction of uterine vessels disallowing adequate blood from entering the placental compartment: histology: thick-walled vessels in decidua/subintimal degenerative change +/- perivascular lymphocytic infiltrates. Identify the cause of the demise with examination of the placenta and fetus: intra-uterine fetal deaths (stillbirths, etiology: placental insufficiency, asphyxia, infection, malformation syndromes, others. Perinatal autopsy: verify malformation if known, ascertain intra-uterine growth and adequacy of placental growth, confirm or change the clinical diagnoses for counselling purposes.