INDS 211 Lecture Notes - Lecture 7: Seminiferous Tubule, Testicular Cancer, Androgen Insensitivity Syndrome
2 Jan 2019
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Document Summary
Composed of seminiferous tubules, which are separated from scrotum by thick, fibrous tunica albuginea. The tunica ends at the hilum of the testis, which is where the tubules connect to the rete testes epididymis vas deferens. Incidence: 6/100000 (worldwide unexplained): gct most: most common form of cancer of men in the 15-35 yrs age group, common testicular cancer resulting in 10% of all cancer deaths, more common in whites than blacks (5:1) Risk factors of gct: cryptorchidism (risk in undescended and contralateral testis, prior hx of testicular gct, risk of developing in other testes increased, androgen insensitivity (testicular feminization) syndrome (5-10% of these pts, familial predisposition, currently unexplained. Round shape, smooth borders, bm thin and regular. There are also several layers of germ cells. There"s thickened bm, arrest in spermatogenesis (can"t find spermatozoa in lumen), normal constituent of epithelium replaced by neoplastic cells (itgcn cells with prominent nucleoli, abundant clear cytoplasm).
