INDS 211 Lecture Notes - Lecture 14: Male Reproductive System, Androgen Receptor, Seminiferous Tubule

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 211
• Professor: Helene Weibel

Document Summary

Because it"s a 10 aa peptide, it gets cleaved quickly so it can"t be used as a drug. Instead both agonists and: contraception: as large amounts shutsdown whole axis. Gonadotropins (lh, fsh) act on gpcr receptor on cells in testes to trigger rapid acting, promoting steroidogenesis. Fsh: acts on sertoli to produce inhibin. used to stimulate female ovulation, not effective in males to. Gonadotropin structure: biological specificity resides in subunit, species specificity resides in subunit. Lh: acts on leydig to produce testosterone. not really used as drug. Less sugar= short half life (10-15 stimulate fertility. life mintues): note: pulses @ 30 min to 2 hours, like gnrh (of course) so much bigger variability in lh estradiol. Steroid receptor: very specific; if mutated, the response changes dramatically. The length of repeats alters biological activity of receptor (eg. some men require more testosterone for a reaction, some require less).