NEUR 310 Lecture Notes - Lecture 6: Red, Metalloproteinase, Eph Receptor A2
3 Feb 2017
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Exam practice question: what happens when there is no ephrina in the tectum, ephrina is a repellent, need to remember experiments. The active rhogtpases interact with effector downstream molecules (rock, pak, wasp, etc) Ephrina signaling: axons that express ephexin, exposed to ephrina, is repelled by the ligand. Review: intracellular signalling mechanisms that regulates f-actin architecture. Fundamental principle that these rhogtp molecules regulates both growth and collapse of the growth cone - even though there are multiple different downstream molecules. They project their axons to the dorsal plate. The response to a specific cue by one population of neurons may vary in different environments (spatially) Intracellular concentrations of cyclic nucleotides regulate the axonal response to guidance cues. Xenopus: spritzed netrin on one side of the plate and observed that most of the neurons were attracted to the cue. Inactive netrin used as a control (ignored by the neuron)
