NEUR 310 Lecture Notes - Lecture 1: Cell Migration, Neural Plate, Zebrafish
4 May 2015
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Document Summary
Development of the nervous system: determination of cell fate. Neural induction: generation the neural tube : cellular proliferation, cellular differentiation. Cortical lamination (mental retardation etc. if not developed well: establishment of cellular communication (neurons that talk to each other) Development to the spinal cord, the closer to the brain is rostral, further is caudal. What would we know without model organisms? (not very much) We relied historically on model organism to discover and modify molecule essential in the development of the nervous system. If we look at various organism very early on development, we find that the embryos are very similar, what they have development, are the nervous tube, the early process are very similar between the species. Xenopus ( great to do transplantation experiment) , zebrafish, chick . Drosophila, c. elegans (easy to study early development using early genetics applying various chemicals and identifying various mutants, and then go back to identify the genes mutated. )
