NUR1 200 Lecture Notes - Lecture 7: Glycogen Phosphorylase, Glycogen Synthase, Glut2
5 May 2016
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Mobilization of glucose from glycogen stores (up to 10% of liver, 1-2% of muscle by weight) Glycogen depleted from liver by 18-24h of fasting & depleted from muscle <1 during exercise. Break down glycogen (glucose stores) in liver or muscles to release free glucose so that body can use the glucose. Glycogen degredation: removing glucose from non-reducing ends) Glycogen has multiple nonreducing ends, thus can provide glucose at a very fast rate. Handled differently depending on tissue needs or function of glycogenolysis product: in muscle: g6p formed from glycogen can immediately enter the glycolytic pathway thus providing a source of energy. Fight or flight response, need to sprint 100m: need energy right away: in liver (& kidney): it is also used to break down glycogen to make glucose go to other parts of body. Glucose molecules then carried out of er and out of cell by transporter molecules.
