PHAR 300 Lecture Notes - Lecture 11: Barbiturate, Chlordiazepoxide, Anxiogenic

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Lecture 11 diazepam drugs to treat mental illness. In the past, mental illness was attributed to demons, but today we know it is caused by abnormalities in the brain. In schizophrenia, there are elevated da levels and the d2 receptor is affected: d2 receptor is inhibitory drugs for schizophrenia act on d2, d2 receptors are found in a variety of places post-synaptically on the. Da and pre-synaptically on other neurons: chlorpromazine was the first effective neuroleptic drug category of phenothiazine drugs that block the da d2 receptor and consequently the symptoms of schizophrenia. Cns: most are gpcrs, but 5ht3 in brain is not it is a ligand-gated ion channel. Ans can still react causes tremors and palpitations: use beta-blockers block beta receptors and stop sensations of heart palpitations and tremors. Gaba is present, you have bigger amount of cl going across = bigger hyperpolarization: inverse agonist: antagonizes the effect of.