PHAR 300 Lecture Notes - Lecture 10: Phospholipase A2, Rheumatoid Arthritis, Proopiomelanocortin

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Hormones: target cells with specific receptors; communicate via the circulation. Hypothalamic control of the pituitary: hypothalamus has direct connection to the posterior pituitary, secretes hormones into the circulation that will affect the anterior pituitary, hypothalamus releases corticotropin which acts on specific cells in the anterior pituitary. It"s a g-protein coupled receptor which triggers an activation process to. Pomc have acth and other hormones that act on different parts of the. Proopiomelanocorticotropin is processed to release acth and beta-lph: acts on the body of different targets, acth stimulates and regulates glucocorticoid synthesis in the adrenal cortex (outside part, acth increases the delivery of cholesterol to the inner mitochondrial membrane. Increases transcription of steroidogenic enzymes, e. g. the p450 side chain o cleavage enzyme (cyp11a1) Acth regulates glucocorticoid synthesis in the zonae fasciculata/reticularis: zonae glomerulosa produces mineralcorticoids. Steroidogenesis: many reactions to get cortisol, passes through many intermediates, very tightly regulated, must be able to regulate transcription of many intermediates.