PHAR 300 Lecture Notes - Lecture 8: Pituitary Gland, Atrioventricular Node, Cardiac Arrhythmia

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Oct. 1, 2015: chronic use: addiction, drug interactions, toxicity, deaths from acute poisoning, among the top killers, large market of selling drugs to kids. Action of cocaine: cocaine acts on impulse coming down nerve fiber, it acts out on the synapse of the re-uptake pump, acts on the re-uptake of dopamine, noradrenaline and serotonin o o. It increases the level of these transmitters in the synapse. Increases transmission in more than one pathway in the brain: has effects on the autonomic system as well, also affects transmission in organs like the heart. Blocks voltage-gated na+ channels: what allows us to move, a high enough of cocaine blocks axonal conduction, some areas are more vulnerable than others o o heart, effects on: It doesn"t just act on the brain, it acts on all excitable tissues. It acts on the spinal cord, autonomic nervous system, conduction system on the. Rapid administration may produce immediate i and death.