PHAR 301 Lecture Notes - Lecture 5: Arylalkylamine, Asthma, Losartan

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 301
• Professor: Barbara Hales

Document Summary

Phar 301 lecture 5: bowie (short notes) Dementia associated with arteriosclerosis in the brain: kidney disease due to organ failure kidneys improperly perfused, some genetic component to cvd but most risk factors are related to lifestyle controllable! Two branches of the ans = parasymp and symp ns (rest and digest & fight or flight, respectively) opposing fxns. Sympathetic: ach nachr machr (sweat glands) Ach nachr ne (cid:417) & (cid:418) (cardiac/smooth muscle) Ach nachr (adrenal medulla) epi, ne. Ne binding to (cid:417)1rs vasoconstriction increased bp. Ne binding to (cid:418)1rs increased force of contraction & hr via second messenger system (gpcr gs) increased bp. Parasympathetic: ach nachr machr (cardiac/smooth muscle: gq increased levels of ip3 & dag increased intracell ca contraction, gi decreased camp opening of k channels hyperpolarisation. Tyrosine dopa (via tyrosine hydroxylase) da ne (via. Choline + acetyl-coa ach (via choline acetyltransferase) 21yo female with frequent episodes of blurred vision, dizziness, faintness and syncope for a very long time.