PHAR 301 Lecture Notes - Lecture 10: Aromatic L-Amino Acid Decarboxylase, Monoamine Oxidase Inhibitor, Monoamine Oxidase B
18 Feb 2016
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Lecture 1 prenatal and pediatric pharmacology: acetaminophen is conjugated to glucuronide and sulfate conjugates. Babies don"t make any glucuronide conjugating enzymes (increases with age), but they do make a lot of sulfate conjugating enzymes. (decreases with age) No problem in babies metabolizing acetaminophen: choloramphenicol needs to be conjugated to glucuronide to be eliminated. Drug accumulates in babies, causing grey baby: bilirubin is the yellow breakdown product of normal syndrome. heme catabolism, caused by the body"s clearance of aged red blood cells which contain hemoglobin. Jaundice in babies is caused by the accumulation of bilirubin, since the liver doesn"t have the ability to get rid of the heme metabolite effectively. (liver glucuronidation is immature) Newborns a lot of impact on phase ii of drug metabolism (conjugation) Lecture 2 geriatric pharmacology and drug interactions (modification: elderly greater impact on phase i of drug metabolism, decreased first pass effect and decreased rate of, warfarin oral anticoagulant biotransformation of some drugs.
