PHAR 303 Lecture Notes - Lecture 12: Cytotoxicity, Dimethylformamide, Thorium Dioxide
22 Mar 2017
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Document Summary
Phar 303 lecture 12: liver toxicity (baglole) It is the most commonly affected organ by commercially produced chemicals and environmental pollutants. Liver lobules it"s in the finer details. There are 100 000 liver lobules in the entire liver and they are the basic functional unit of the liver. Separated from each other by interlobular septum like spokes on a wheel consists of a central vein surrounded by hepatic portal veins, hepatic arteries and small branches of bile duct. The hepatic triad = portal venules, portal arteriole, bile duct. Form a layer surrounding the liver sinusoids that it a single cell in thickness. Multiplicity of toxin-induced interactions between sinusoidal cells and hepatocytes. Vit a activation of kcs increase ccl4 acute toxicity: by itself, ccl4 is hepatotoxic but if you add vit a on top, due to the activation of the kcs, it can potentiate damage.
