PHAR 562 Lecture Notes - Lecture 11: Monoamine Neurotransmitter, Competitive Inhibition, Human Settlement
8 Sep 2017
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Noradrenergic pathways: neuromodulator system, two main places: lc projects into cortex/cerebellum, rf into spinal cord, not conventional synapses na diffuses out in a process called volume transmission, deficits have been linked to depression, dementia, diminished alertness/concentration. Monoamine transmission is a therapeutic transmission: da important in pd, na alertness, stress, ptsd, 5-ht also a part of these systems, there are transporter systems for each nt: dat, nat, sert. Adrenergic receptor and volume transmission: there is a varicosity in the axon, and when it is depolarised, na will be released. It then moves into an inward-open configuration to transport nt and na: most of the transporter is a scaffold, with alpha helical regions (tm1/6) moving. Adrenergic receptors: a and b receptors are linked to different effector systems, b-receptors are involved in elevating camp, a-receptors are involved with phospholipase c (plc) or adenylate cyclase.
