PHAR 562 Lecture Notes - Lecture 1: Cell Membrane, Astrocyte, Locus Coeruleus
12 Oct 2017
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The brain develops up to young adult and then starts degenerating. If there is an earthquake right now, sensory function takes over higher functions and we stop paying attention to class: we have the ability to switch importance between the three functions. Neurotransmitters: excitatory: glutamate, inhibitory: mainly gaba, glycine is in the spinal cord, excitatory (glutamate) and inhibitory (gaba/glycine) neurotransmitters are the. Hardwiring: what makes you you are the other neurotransmitters (biogenic amines, choline derivatives, etc) that regulate the inhibitory/excitatory neurotransmitters, most neuro diseases arise from defects in these neurotransmitter systems. Glutamate: the chemical structure is very simple, metabotropic receptors: gpcr, glutamatergic pathways are everyway, all neurons have glutamate receptors, any drugs that act on anything within glutaminergic pathway is not very specific. Gaba: to make gaba, you need to go through glutamate, there are few neurons without gaba a receptors, most drugs are gaba drugs, they are everywhere. Gaba/glutamate are secreted in discrete packages at synapses.
