PHAR 562 Lecture Notes - Lecture 10: Cyclic Adenosine Monophosphate, Norepinephrine Transporter, Reuptake
24 Oct 2017
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Document Summary
Adrenergic receptor and volume transmission: there is a varicosity in the axon, and when it is depolarised, na will be released. Intracell cascades that are involved in st and lt plasticity originally proposed for ltp: st memory cascades, nmdar and ca-dependent, activation of camp cascade by ac activation of. In humans, comt is encoded by the comt gene: regulation of catecholamines is impaired in a number of medical conditions, several pharma drugs target. Comt to alter its activity and therefore, the availability of catecholamines. Distribution: cns, both maoa and b are found in neurons + astroglia, periphery, maoa is also found in: liver, pulmonary vascular endothelial cells, git, placenta, maob mostly found in blood platelets. Involved in the inactivation of the catecholamine nts da, na and epi: any compound having a catechol structure like catecholestrogens and catechol-containing flavonoids are. Inhibitors of comt are used in tx of parkinson"s disease.
