PHGY 209 Lecture Notes - Lecture 14: Royal Aircraft Factory F.E.2, Erythropoiesis, New World Oriole
30 Oct 2016
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Regulation of erythropoiesis: produced in the kidney, in the presence of hypoxia, decrease in o2, stimulate increase release of erythropoietin, transported to plasma, move to bone marrow, stimulate rbc production, oxygen supply increases. Acts on the committed stem cell: stimulates proliferation, accelerates maturation. Testosterone: increases the release of erythropoietin, sensitivity of rbc precursors to erythropoietin. Life span is about 120 days: each rbc travels about 300 miles. Removed by highly phagocytic cells known as macrophages: inside are many lysosomes and digestive enzymes, hemoglobin is released. Stored in liver spleen, gut, ferritin storage. Maybe carried directly to bone marrow to be reutilized: heme broken up. Picked up by liver, and into bile. If higher it may be deposited in other places. Juandice (icterus: deposited in the white of the eyes, makes it look yellow. May develop in: liver disease, excessive hemolysis. Liver is deceased: common bile duct obstruction.
