PHGY 209 Lecture Notes - Lecture 26: Apoptosis, Innate Immune System, Mhc Class I

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: Ann Wechsler

Document Summary

The end produce is released into the cell, killing the cell and forms the net. Natural killer cell: it has to be turned on, wanders through the body trying to find abnormal cells. Mhc class i molecule on normal cells is recognized by killer cell immunoglubin-like receptors (kirs) or by lactin-like. Nk cell doesn"t kill the normal cell. Absence mhc or altered mhc cannot stimulate negative signal. The nk cell is triggered by signals from activating: activated nk release granule contents, inducing apoptosis (kill any normal cell, ex. Alternative pathway: pathogen associated membrane p (pamp) is the activating factor, pamp activates compliment activation in another way, does this the same way every time. Opsonization makes the bacteria tastier for the neutrophils, coats tehm. Series of molecular pathway, blowing a hole in the bacteria: the greater part of what we talk about is bacterial killing.