PHGY 209 Lecture Notes - Lecture 38: Excitatory Postsynaptic Potential, Excitatory Synapse, Synaptic Plasticity
Document Summary
Topic vi nervous system (lecture oct 24) Whole bunch of different kinds of ligand-gated ion channels: nonetheless, all opened by binding a specific type of neurotransmitter, neurotransmitters changes electrical properties of post-synaptic cell. More or less likely to fire action potential. A diagra(cid:373) of ho(cid:449) the (cid:272)al(cid:272)iu(cid:373) i(cid:374)du(cid:272)tio(cid:374) a(cid:272)tually (cid:449)orks . Complex of proteins holding synaptic vesicle at the active zone involved in the docking process. Calcium channel actually part of protein complex holding the vesicle in place. Ie the channel itself very close to synaptic vesicles: this helps with diffusion since it is located in proximity of the plasma membrane, thus concentration at that regions raises rather quickly. Although the [] in the whole cell barely goes up at all: toxins acting on this vesicle complex: botox, tetanus toxins etc. Taken up by pre-synaptic terminal from ec space. Act as proteases = degrade some of the key proteins.
