PHGY 209 Lecture Notes - Lecture 4: Cytosol, Electric Charge, Motility
15 Apr 2018
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Document Summary
Even if the charges of ions are balanced, the membrane has a negative potential. Passage of these molecules are mediated by transporters facilitated diffusion- the net flux of a molecule across a membrane always proceeds from a higher to lower []. It uses a transporter to move solute: glucose transporters or glut. Each glut is coded for by different genes. Transporter with atp binds three na (there are 2 for k) ions on the transcellular surface. Binding of na resulting in activation of an inherent. Atpase activity of the transporter protein, causing phospjorylation of the cytosolic surface of the transporter and release a molecule of adp. This results in the conformational change of the transporter which results in increased affinity of the two binding sites for k, allowing two molecules of k to bind to the transporter on the extracellular surface. Binding of k results in dephophrylation of the transporter resulting in the original conformation.
