PHGY 210 Lecture Notes - Lecture 4: Diabetic Coma, Pancreas, Metabolic Acidosis
3 Feb 2018
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Document Summary
Characterized by failure of the adrenal cortex to produce adrenocortical hormones (cortisol and aldosterone) May involve total destruction of the gland. Mostly due to atrophy of the adrenal glands due to tuberculosis and involves medulla as well as the cortex. The most important deficiencies with mineralocorticoid deficiency (aldosterone) are: ion imbalances: hyperkalemia and acidosis, the mineral imbalance can lead to death in 7 days if left unchecked due to shock. Glucocorticoid deficiency leads to: decreased gluconeogenesis in the liver, the lack of energy as most tissues uses glucose as the energy source. Characterized by hyperplasia of adrenal cortex due to lack of control/increased acth production. On top of metabolism effects, the excessive production of glucocorticoids can lead to masculinizing effect in female. Treatment often includes surgery, either in the adrenal cortex or even in the pituitary if the problem lies with. 99% of the organ is exocrine and secretes the digestive enzymes.
