Failure of adrenal cortex to produce enough adrenocortical hormones (both glucocorticoid & May be caused by destruction of the gland. Or more commonly due to atrophy of adrenal gland due to tuberculosis. Glucocorticoid deficiency (responsible for upregulating metabolism and blood sugar levels) Lack of energy, muscular weakness and inability to take stress. Mineralocorticoid deficiency (responsible for controlling electrolyte levels, retaining sodium) Decreased retention of na+ (hyponatremia), cl- and water in urine. Decreased extracellular fluid, plasma volume and cardiac ouput. Increased k+ (hyperkalemia) and h+ (acidosis) retention, since normally exchanged for na+ Patient die in shock 7 days after complete absence of mineralocorticoids. Surplus of acth leading to hyperplasia of adrenal cortex and excessive production of glucocorticoids and mineralocorticoids. Can lead to burn out of -cells in pancreas, leading to diabetes. Osteoporosis from loss of protein matrix leading to eventual loss of calcium (not enough matrix) Increased retention of na+ (hypernatrimia), cl- and water.