PHGY 210 Lecture Notes - Lecture 6: Respiratory Alkalosis, Metabolic Alkalosis, Respiratory Acidosis
27 Nov 2015
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Renal physiology lecture 6: hydrogen ion regulation & diuretics and kidney disease. Low h+ concentration (high ph): alkalosis: respiratory alkalosis (results from altered respiration, metabolic alkalosis (results from other causes) High h+ concentration (low ph): acidosis: respiratory acidosis (results from altered respiration, metabolic acidosis (results from other causes) Responses to acidosis (high h+ concentration: sufficient h+ are secreted to reabsorb all the filtered hco3. To the plasma as these h+ are: still more h+ are secreted and this contributes new hco3 excreted bound to non-hco3. 2: tubular glutamine metabolism and ammonium excretion are enhanced, which also contributes new hco3. Than usual are added to the plasma, thereby compensating for the acidosis. The urine is highly acidic (lowest attainable ph=4. 4) Responses to alkalosis (low h+ concentration: rate of h+ secretion is inadequate to reabsorb all the filtered hco3. Net result: plasma hco3 will decrease, thereby compensating for the alkalosis. The urine is highly alkaline (ph > 7. 4)
