PHGY 312 Lecture Notes - Lecture 3: Renal Blood Flow, Renal Artery, Renal Medulla
24 May 2016
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Phgy 312-lecture 3: renal plasma flow and regulation of renal blood flow. Renal artery interlobar artery arcuate artery interlobular artery afferent arteriole glomerular capillaries efferent arteriole peritubular capillaries vasa recta interlobular vein arcuate vein interlobar vein renal vein. Renal blood flow (rbf: indirectly determines the gfr, modifies rate of solute/water reabsorption by pct, concentration and dilution of urine, delivers o2, nutrients to the nephron, delivers substrate for excretion in urine. Pxa rpfa = (pxv rpfv) + (ux v ) [input (artery) = output (vein + ureter)] Volume of plasma from which all the substance has been removed & excreted into the urine/unit time. Assumed that substances not synthesized or metabolized by the kidney. Clearance=c= ([urine] v)/[plasma] (1) pxa ux v, (2) pxa x cx = ux x v". Grf estimated from clearance of creatinine in humans (filtered only) o. Pcr x rpf = pcr x gfr = ucr x v".
