PHGY 312 Lecture Notes - Lecture 6: Renal Glucose Reabsorption, Cell Membrane, Glucose Transporter

• School: McGill University
• Department: Physiology
• Course: PHGY 312
• Professor: Russell Jones

Document Summary

Lots of organic solutes are filtered through the pct. Under normal conditions, plasma levels of glucose are 5mm (180l filtered/day) Clearance of glucose is 0! (glucose is reabsorbed completely) When glucose is in the lumen, it"s taken up by 2nd active transport into the epithelial cells. Once glucose is high conc inside the cell, all you need is a facilitated diffusion via glut2. Functional method of cloning genes based on their known properties. Allows you to find molecules based on their functions. Involved in the active transport of glucose and galactose into cells. Found based on hybridization of clone to probe based on slgt1. Sglt2 is the major cotransporter involved in glucose reabsorption in the kidney. Inhibition of sglt2 leads to a reduction in blood glucose levels. (gfr x ps) = (us x v") +ts, amount entering=amount leaving, ts = (gfr x ps) (us x v")